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Lisa's Substitute is the nineteenth episode of season 2. It originally aired on April 25, 1991. It was written by Jon Vitti and directed by Rich Moore. Dustin Hoffman–using the pseudonym Sam Etic–guest starred in it as Mr. Bergstrom. The episode features cultural references to Mike Nichols's film The Graduate, which starred Hoffman, and the novel Charlotte's Web by E. B. White.

When Lisa's teacher Miss Hoover gets Lyme Disease, Mr. Bergstrom takes over the class. Lisa finds Mr. Bergstrom's teaching methods incredibly inspiring and discovers an entirely new love for learning, but when Mr. Bergstrom leaves, Lisa doubts that anyone else in her life (including her own father) can be the man that Mr. Bergstrom was. Meanwhile, Bart runs against Martin Prince, Jr. for class president...